Publications
2023
Gail Is Harmata,
Giovanni Battistella and Kristina Simonyan. 2023. “Clinical implications of dystonia as a neural network disorder.” Advances in Neurobiology. 31:223-240. Full text.pdf
Stefan K Ehrlich, Giovanni Battistella, and Kristina Simonyan. 2023. “Temporal signature of task-specificity in isolated focal laryngeal dystonia.” Movement Disorders, Jul 25. Full text.pdf
Lena C O’Flynn, Steven J Frucht, and Kristina Simonyan. 2023. “Sodium oxybate in alcohol-responsive essential tremor of voice: An open-label phase II study.” Movement Disorders, Jul 14. Full text.pdf
Dongren Yao, Lena C O’Flynn, and Kristina Simonyan. 2023. “DystoniaBoTXNet: Novel Neural Network Biomarker of Botulinum Toxin Efficacy in Isolated Dystonia.” Annals of Neurology, Mar;93(3):460-471. Full text.pdf
Jana Schill, Kristina Simonyan, Simon Lang, Christian Mathys, Christiane Thiel, and Karsten Witt. 2023. “Parkinson’s Disease Speech Production Network as Determined by Graph-Theoretical Network Analysis.” Network Neuroscience, Jun 30;7(2):712-730. Full text.pdf
Saul A Frankford, Lena O Flynn, and Kristina Simonyan. 2023. “Sensory processing in the auditory and olfactory domains is normal in laryngeal dystonia.” Journal of Neurology, Apr;270(4):2184-2190. Full text.pdf
2022
Kristina Simonyan, Stefan Ehrlich, Richard Andersen, Jonathan Brumberg, Frank Guenther, Mark Hallett, Matthew A Howard, José R. del Millán, Richard B Reilly, Tanja Schultz, and Davide Valeriani. 2022. “Brain-computer interfaces for treatment of focal dystonia.” Movement Disorders, 37, 9, Pp. 1798-1802. PDF
Davide Valeriani, Lena C. O’Flynn, Alexis Worthley, Azadeh Hamzehei Sichani, and Kristina Simonyan. 2022. “Multimodal collaborative brain-computer interfaces aid human-machine team decision-making in a pandemic scenario.” Journal of Neural Engineering, Oct 17;19(5). PDF
Lena Carolyn O’Flynn and Kristina Simonyan. 2022. “Short- and long-term cental action of botulinum neurotoxin treatment in laryngeal dystonia.” Neurology, 99, 11, Pp. e1178-e119. PDF
Laura Lima de Xavier and Kristina Simonyan. 2022. “Voice tremor.” In Tremors. Oxford University Press. PDF
2021
Jana Schill, Kirsten E. Zeuner, Arne Knutzen, Inken Tödt, Kristina Simonyan, and Karsten Witt. 2021. “Functional Neural Networks in Writer’s Cramp as Determined by Graph-Theoretical Analysis.” Frontiers in Neurology, Nov 23;12:744503. Full text.pdf
Kristina Simonyan, Julie Barkmeier-Kraemer, Andrew Blitzer, Mark Hallett, John F Houde, Teresa Jacobson Kimberley, Laurie J Ozelius, Michael J Pitman, Robert Mark Richardson, Nutan Sharma, and Kristine Tanner. 2021. “Laryngeal Dystonia: Multidisciplinary Update on Terminology, Pathophysiology, and Research Priorities.” Neurology, 96, 21:989-1001. Full text.pdf
Alexis Worthley and Kristina Simonyan. 2021. “Suicidal Ideations and Attempts in Patients with Isolated Dystonia.” Neurology, Mar 16;96(11):e1551-e1560. Full text.pdf Editorial by KE Zeuner and JA van Gerpen
Aria Jafari, Laura de Lima Xavier, Jeffrey D Bernstein, Kristina Simonyan, and Benjamin S Bleier. 2021. “Association of Sinonasal Inflammation With Functional Brain Connectivity.” JAMA Otolaryngology Head and Neck Surgery Jun 1;147(6):534-543. Full text.pdf
Davide Valeriani and Kristina Simonyan. 2021. “The dynamic connectome of speech control.” Philosophical Transactions of the Royal Society B, 376, 1836. PDF Supplementary material
Sanaz Khosravani, Gang Chen, Laurie J Ozelius, and Kristina Simonyan. 2021. “Neural endophenotypes and predictors of laryngeal dystonia penetrance and manifestation.” Neurobiology of Disease, Jan;148:105223. Full text.pdf2020
Laura de Lima Xavier and Kristina Simonyan. 2020. “Neural Representations of the Voice Tremor Spectrum.” Movement Disorders Dec;35(12):2290-2300.
Full text.pdf
Davide Valeriani and Kristina Simonyan. 2020. “A microstructural neural network biomarker for dystonia diagnosis identified by a DystoniaNet deep learning platform.” Proceedings of the National Academy of Sciences USA Oct 20;117(42):26398-26405. Full text.pdf SI Appendix.pdf
Codrin Lungu, Laurie Ozelius, David Standaert, Mark Hallett, Beth-Anne Sieber, Christine Swanson-Fisher, Brian D Berman, Nicole Calakos, Jennifer C Moore, Joel S Perlmutter, Sarah E Pirio Richardson, Rachel Saunders-Pullman, Laura Scheinfeldt, Nutan Sharma, Roy Sillitoe, Kristina Simonyan, Philip A Starr, Anna Taylor, Jerrold Vitek, and NINDS Workshop Research Priorities participants and organizers of the on in Dystonia. 2020. “Defining research priorities in dystonia.” Neurology Mar 24;94(12):526-537. Full text.pdf
Sandra Hanekamp and Kristina Simonyan. 2020. “The large-scale structural connectome of task-specific focal dystonia.” Human Brain Mapping Aug 15;41(12):3253-3265. Full text.pdf
Lena C. O’Flynn, Alexis Worthley, and Kristina Simonyan. 2020. “Neural Control of the Laryngopharynx.” In: Laryngopharyngeal and Gastroesophageal Reflux, pp. 39-44. Springer, Cham. Full text.pdf
Fiachra Maguire, Richard B Reilly, and Kristina Simonyan. 2020. “Normal temporal discrimination in musician’s dystonia is linked to aberrant sensorimotor processing.” Movement Disorders May;35(5):800-807. Full text.pdf
2019
Laura Lima de Xavier, Sandra Hanekamp, and Kristina Simonyan. 2019. “Sexual Dimorphism Within Brain Regions Controlling Speech Production.” Frontiers in Neuroscience Jul 30;13:795. Full text.pdf
Giovanni Battistella and Kristina Simonyan. 2019. “Top-down alteration of functional connectivity within the sensorimotor network in focal dystonia.” Neurology. Full text.pdf
Laura de Lima Xavier and Kristina Simonyan. 2019. “The extrinsic risk and its association with neural alterations in spasmodic dysphonia.” Parkinsonism and Related Disorders Aug;65:117-123. Full text.pdf
Serena Bianchi, Stefan Fuertinger, Hailey Huddleston, Steven J Frucht, and Kristina Simonyan. 2019. “Functional and structural neural bases of task specificity in isolated focal dystonia.” Movement Disorders Apr;34(4):555-563. Full text.pdf
Kristina Simonyan. 2019. “Recent advances in understanding the role of the basal ganglia.” F1000Res Jan 30;8:F1000 Faculty Rev-122. Full text.pdf
2018
Kristina Simonyan. 2018. “Neuroimaging Applications in Dystonia.” International Review in Neurobiology, 143:1-30. Full text.pdf
Kristina Simonyan, Steven J Frucht, Andrew Blitzer, Azadeh Hamzehei Sichani, and Anna F Rumbach. 2018. “A novel therapeutic agent, sodium oxybate, improves dystonic symptoms via reduced network-wide activity.” Scientific Reports Oct 31;8(1):16111. Full text.pdf
Samantha Guiry, Alexis Worthley, and Kristina Simonyan. 2018. “A separation of innate and learned vocal behaviors defines the symptomatology of spasmodic dysphonia.” Laryngoscope Jul;129(7):1627-1633. Full text.pdf
Stefan Fuertinger and Kristina Simonyan. 2018. “Task-specificity in focal dystonia is shaped by aberrant diversity of a functional network kernel.” Movement Disorders Dec;33(12):1918-1927. Full text.pdf
Niv Mor, Kristina Simonyan, and Andrew Blitzer. 2018. “Central voice production and pathophysiology of spasmodic dysphonia.” Laryngoscope Jan;128(1):177-183. Full text.pdf
Giovanni Battistella, Veena Kumar, and Kristina Simonyan. 2018. “Connectivity profiles of the insular network for speech control in healthy individuals and patients with spasmodic dysphonia.” Brain Structure and Function Jun;223(5):2489-2498. FullText.pdf
Stefan Fuertinger, Joel C Zinn, Ashwini D Sharan, Farid Hamzei-Sichani, and Kristina Simonyan. 2018. “Dopamine drives left-hemispheric lateralization of neural networks during human speech.” Journal of Comparative Neurology Apr 1;526(5):920-931. FullText.pdf
Ikuo Masuho, Sreenivas Chavali, Brian S Muntean, Nickolas K Skamangas, Kristina Simonyan, Dipak N Patil, Grant M Kramer, Laurie Ozelius, Madan M Babu, and Kirill A Martemyanov. 2018. “Molecular Deconvolution Platform to Establish Disease Mechanisms by Surveying GPCR Signaling.” Cell Reports Jul 17;24(3):557-568.e5. Full text.pdf
Andrew Blitzer, Mitchell F Brin, Kristina Simonyan, Laurie J Ozelius, and Steven J Frucht. 2018. “Phenomenology, genetics, and CNS network abnormalities in laryngeal dystonia: A 30-year experience.” Laryngoscope Jan;128 Suppl 1(Suppl 1):S1-S9. Full text.pdf
Gregory Garbès Putzel, Giovanni Battistella, Anna F Rumbach, Laurie J Ozelius, Mert R Sabuncu, and Kristina Simonyan. 2018. “Polygenic Risk of Spasmodic Dysphonia is Associated With Vulnerable Sensorimotor Connectivity.” Cerebral Cortex Jan 1;28(1):158-166. Full text.pdf
2017
Serena Bianchi, Giovanni Battistella, Hailey Huddleston, Rebecca Scharf, Lazar Fleysher, Anna F Rumbach, Steven J Frucht, Andrew Blitzer, Laurie J Ozelius, and Kristina Simonyan. 2017. “Phenotype- and genotype-specific structural alterations in spasmodic dysphonia.” Movement Disorders, Apr;32(4):560-568. Full text.pdf
Owen Killian, Eavan M McGovern, Rebecca Beck, Ines Beiser, Shruti Narasimham, Brendan Quinlivan, Sean O’Riordan, Kristina Simonyan, Michael Hutchinson, and Richard B Reilly. 2017. “Practice does not make perfect: Temporal discrimination in musicians with and without dystonia.” Movement Disorders, Dec;32(12):1791-1792. Full text.pdf
Franca Vulinovic, Susen Schaake, Aloysius Domingo, Kishore Raj Kumar, Giovanni Defazio, Pablo Mir, Kristina Simonyan, Laurie J Ozelius, Norbert Brüggemann, Sun Ju Chung, Aleksandar Rakovic, Katja Lohmann, and Christine Klein. 2017. “Screening study of TUBB4A in isolated dystonia.” Parkinsonism and Related Disorders, Aug;41:118-120. Full text.pdf
Stefan Fuertinger and Kristina Simonyan. 2017. “Connectome-Wide Phenotypical and Genotypical Associations in Focal Dystonia.” Journal of Neuroscience Aug 2;37(31):7438-7449. Full text.pdf
Kristina Simonyan, Hyun Cho, Azadeh Hamzehei Sichani, Estee Rubien-Thomas, and Mark Hallett. 2017. “The direct basal ganglia pathway is hyperfunctional in focal dystonia.” Brain Dec 1;140(12):3179-3190. Full text.pdf Commentary by K Fujita and D Eidelberg
Giovanni Battistella, Pichet Termsarasab, Ritesh A Ramdhani, Stefan Fuertinger, and Kristina Simonyan. 2017. “Isolated Focal Dystonia as a Disorder of Large-Scale Functional Networks.” Cerebral CortexFeb 1;27(2):1203-1215. Full text.pdf
Diana N Kirke, Giovanni Battistella, Veena Kumar, Estee Rubien-Thomas, Melissa Choy, Anna Rumbach, and Kristina Simonyan. 2017. “Neural correlates of dystonic tremor: a multimodal study of voice tremor in spasmodic dysphonia.” Brain Imaging and Behavior Feb;11(1):166-175. Full text.pdf
Anna F Rumbach, Andrew Blitzer, Steven J Frucht, and Kristina Simonyan. 2017. “An open-label study of sodium oxybate in Spasmodic dysphonia.” Laryngoscope, Jun;127(6):1402-1407. Full text.pdf
2016
G Battistella, S Fuertinger, L Fleysher, LJ Ozelius, and K Simonyan. 2016. “Cortical sensorimotor alterations classify clinical phenotype and putative genotype of spasmodic dysphonia.” European Journal of Neurology, Oct;23(10):1517-27. Full text.pdf
Joseph E Rittiner, Zachary F Caffall, Ricardo Hernández-Martinez, Sydney M Sanderson, James L Pearson, Kaylin K Tsukayama, Anna Y Liu, Changrui Xiao, Samantha Tracy, Miranda K Shipman, Patrick Hickey, Julia Johnson, Burton Scott, Mark Stacy, Rachel Saunders-Pullman, Susan Bressman, Kristina Simonyan, Nutan Sharma, Laurie J Ozelius, Elizabeth T Cirulli, and Nicole Calakos. 2016. “Functional Genomic Analyses of Mendelian and Sporadic Disease Identify Impaired eIF2α Signaling as a Generalizable Mechanism for Dystonia.” Neuron, Dec 21;92(6):1238-1251. Full text.pdf
Gregory G Putzel, Tania Fuchs, Giovanni Battistella, Estee Rubien-Thomas, Steven J Frucht, Andrew Blitzer, Laurie J Ozelius, and Kristina Simonyan. 2016. “GNAL mutation in isolated laryngeal dystonia.” Movement Disorders, May;31(5):750-5. Full text.pdf
Stefan Fuertinger, Kristina Simonyan, Michael R Sperling, Ashwini D Sharan, and Farid Hamzei-Sichani. 2016. “High-frequency brain networks undergo modular breakdown during epileptic seizures.” Epilepsia, Jul;57(7):1097-108. Full text.pdf
Pichet Termsarasab, Ritesh A Ramdhani, Giovanni Battistella, Estee Rubien-Thomas, Melissa Choy, Ian M Farwell, Miodrag Velickovic, Andrew Blitzer, Steven J Frucht, Richard B Reilly, Michael Hutchinson, Laurie J Ozelius, and Kristina Simonyan. 2016. “Neural correlates of abnormal sensory discrimination in laryngeal dystonia.” Neuroimage Clinicanl, Oct 30;10:18-26. Full text.pdf
Kristina Simonyan, Hermann Ackermann, Edward F Chang, and Jeremy D Greenlee. 2016. “New Developments in Understanding the Complexity of Human Speech Production.” Journal of Neuroscience, Nov 9;36(45):11440-11448. Full text.pdf
Stefan Fuertinger and Kristina Simonyan. 2016. “Stability of Network Communities as a Function of Task Complexity.” Journal of Cognitive Neuroscience, Dec;28(12):2030-2043. Full text.pdf
Veena Kumar, Paula L Croxson, and Kristina Simonyan. 2016. “Structural Organization of the Laryngeal Motor Cortical Network and Its Implication for Evolution of Speech Production.” Journal of Neuroscience, Apr 13;36(15):4170-81. Full text.pdf
2015
Diana N Kirke, Steven J Frucht, and Kristina Simonyan. 2015. “Alcohol responsiveness in laryngeal dystonia: a survey study.” Journal of Neurology, Jun;262(6):1548-56. Full text.pdf
Stefan Fuertinger, Barry Horwitz, and Kristina Simonyan. 2015. “The Functional Connectome of Speech Control.” PLoS Biology, Jul 23;13(7):e1002209. Full text.pdf
Catherine F Sinclair, Kristina Simonyan, Mitchell F Brin, and Andrew Blitzer. 2015. “Negative dystonia of the palate: a novel entity and diagnostic consideration in hypernasal speech.” Laryngoscope, Jun;125(6):1426-32. Full text.pdf
Kristina Simonyan and Stefan Fuertinger. 2015. “Speech networks at rest and in action: interactions between functional brain networks controlling speech production.” Journal of Neurophysiology, Apr 1;113(7):2967-78. Full text.pdf
2014
Kristina Simonyan. 2014. “The laryngeal motor cortex: its organization and connectivity.” Current Opinion in Neurobiology, Oct;28:15-21. Full text.pdf
Stefan Fürtinger, Joel C Zinn, and Kristina Simonyan. 2014. “A neural population model incorporating dopaminergic neurotransmission during complex voluntary behaviors.” PLoS Computational Biology, Nov 13;10(11):e1003924. Full text.pdf
Barry Horwitz and Kristina Simonyan. 2014. “PET neuroimaging: plenty of studies still need to be performed: comment on Cumming: “PET neuroimaging: the white elephant packs his trunk?”” Neuroimage, Jan 1;84:1101-3. Full text.pdf
Ritesh A Ramdhani, Veena Kumar, Miodrag Velickovic, Steven J Frucht, Michele Tagliati, and Kristina Simonyan. 2014. “What’s special about task in dystonia? A voxel-based morphometry and diffusion weighted imaging study.” Movement Disorders, Aug;29(9):1141-50. Full text.pdf
2013
Kristina Simonyan, Brian D Berman, Peter Herscovitch, and Mark Hallett. 2013. “Abnormal striatal dopaminergic neurotransmission during rest and task production in spasmodic dysphonia.” Journal of Neuroscience, Sep 11;33(37):14705-14. Full text.pdf
Kristina Simonyan and Steven J Frucht. 2013. “Long-term Effect of Sodium Oxybate (Xyrem®) in Spasmodic Dysphonia with Vocal Tremor.” Tremor and Other Hyperkinetic Movements (N Y), Dec 9;3:tre-03-206-4731-1. Full text.pdf
Ritesh A Ramdhani and Kristina Simonyan. 2013. “Primary dystonia: conceptualizing the disorder through a structural brain imaging lens.” Tremor and Other Hyperkinetic Movements (N Y), Apr 18;3:tre-03-152-3638-4. Full text.pdf
Kristina Simonyan, Peter Herscovitch, and Barry Horwitz. 2013. “Speech-induced striatal dopamine release is left lateralized and coupled to functional striatal circuits in healthy humans: a combined PET, fMRI and DTI study.” Neuroimage, Apr 15;70:21-32. Full text.pdf
Brian D Berman, Mark Hallett, Peter Herscovitch, and Kristina Simonyan. 2013. “Striatal dopaminergic dysfunction at rest and during task performance in writer’s cramp.” Brain, Dec;136(Pt 12):3645-58. Full text.pdf
Katja Lohmann, Robert A Wilcox, Susen Winkler, Alfredo Ramirez, Aleksandar Rakovic, Jin-Sung Park, Björn Arns, Thora Lohnau, Justus Groen, Meike Kasten, Norbert Brüggemann, Johann Hagenah, Alexander Schmidt, Frank J Kaiser, Kishore R Kumar, Katja Zschiedrich, Daniel Alvarez-Fischer, Eckart Altenmüller, Andreas Ferbert, Anthony E Lang, Alexander Münchau, Vladimir Kostic, Kristina Simonyan, Marc Agzarian, Laurie J Ozelius, Antonius PM Langeveld, Carolyn M Sue, Marina AJ Tijssen, and Christine Klein. 2013. “Whispering dysphonia (DYT4 dystonia) is caused by a mutation in the TUBB4 gene.” Annals of Neurology, Apr;73(4):537-45. Full text.pdf
2012
Kristina Simonyan and Christy L Ludlow. 2012. “Abnormal structure-function relationship in spasmodic dysphonia.” Cerebral Cortex, Feb;22(2):417-25. Full text.pdf
Kristina Simonyan, Xin Feng, Victor M Henriquez, and Christy L Ludlow. 2012. “Combined laryngeal inflammation and trauma mediate long-lasting immunoreactivity response in the brainstem sensory nuclei in the rat.” Frontiers in Integrative Neuroscience, Nov 15;6:97. Full text.pdf
Kristina Simonyan and Andrew Blitzer. 2012. “Commentary on “Bilateral cerebellar stroke presenting with acute dysphonia and late palatal tremor”.” Movement Disorders, Mar;27(3):348. Full text.pdf
Kristina Simonyan, Barry Horwitz, and Erich D Jarvis. 2012. “Dopamine regulation of human speech and bird song: a critical review.” Brain and Language, Sep;122(3):142-50. Full text.pdf
2011
Kristina Simonyan and Barry Horwitz. 2011. “Laryngeal motor cortex and control of speech in humans.” Neuroscientist, Apr;17(2):197-208. Full text.pdf
Fatima T Husain, Roberto E Medina, Caroline W Davis, Yvonne Szymko-Bennett, Kristina Simonyan, Nathan M Pajor, and Barry Horwitz. 2011. “Neuroanatomical changes due to hearing loss and chronic tinnitus: a combined VBM and DTI study.” Brain Research, Jan 19;1369:74-88. Full text.pdf
2010
Kristina Simonyan and Christy L Ludlow. 2010. “Abnormal activation of the primary somatosensory cortex in spasmodic dysphonia: an fMRI study.” Cerebral Cortex, Nov;20(11):2749-59. Full text.pdf
Kristina Simonyan, Christy L Ludlow, and Alexander O Vortmeyer. 2010. “Brainstem pathology in spasmodic dysphonia.” Laryngoscope, Jan;120(1):121-4. Full text.pdf
2009
Kristina Simonyan, John Ostuni, Christy L Ludlow, and Barry Horwitz. 2009. “Functional but not structural networks of the human laryngeal motor cortex show left hemispheric lateralization during syllable but not breathing production.” Journal of Neuroscience, Nov 25;29(47):14912-23. Full text.pdf
2008
Kristina Simonyan, Fernanda Tovar-Moll, John Ostuni, Mark Hallett, Victor F Kalasinsky, Michael R Lewin-Smith, Elisabeth J Rushing, Alexander O Vortmeyer, and Christy L Ludlow. 2008. “Focal white matter changes in spasmodic dysphonia: a combined diffusion tensor imaging and neuropathological study.” Brain, Feb;131(Pt 2):447-59. Full text.pdf
Soren Y Lowell, Christopher J Poletto, Bethany R Knorr-Chung, Richard C Reynolds, Kristina Simonyan, and Christy L Ludlow. 2008. “Sensory stimulation activates both motor and sensory components of the swallowing system.” Neuroimage, Aug 1;42(1):285-95. Full text.pdf
2007
Kristina Simonyan, Ziad S Saad, Torrey MJ Loucks, Christopher J Poletto, and Christy L Ludlow. 2007. “Functional neuroanatomy of human voluntary cough and sniff production.” Neuroimage, Aug 15;37(2):401-9. Full text.pdf
Torrey MJ Loucks, Christopher J Poletto, Kristina Simonyan, Catherine L Reynolds, and Christy L Ludlow. 2007. “Human brain activation during phonation and exhalation: common volitional control for two upper airway functions.” Neuroimage, May 15;36(1):131-43. Full text.pdf
2005
Kristina Simonyan and Uwe Jürgens. 2005. “Afferent cortical connections of the motor cortical larynx area in the rhesus monkey.” Neuroscience, 130(1):133-49. Full text.pdf
Kristina Simonyan and Uwe Jürgens. 2005. “Afferent subcortical connections into the motor cortical larynx area in the rhesus monkey.” Neuroscience, 130(1):119-31. Full text.pdf
2004
Ralph MW Rödel, Arno Olthoff, Frithjof Tergau, Kristina Simonyan, Dorit Kraemer, Holger Markus, and Eberhard Kruse. 2004. “Human cortical motor representation of the larynx as assessed by transcranial magnetic stimulation (TMS).” Laryngoscope, May;114(5):918-22. Full text.pdf
2003
Kristina Simonyan and Uwe Jürgens. 2003. “Efferent subcortical projections of the laryngeal motorcortex in the rhesus monkey.” Brain Research, Jun 6;974(1-2):43-59. Full text.pdf
2002
. 2002. “Cortico-cortical projections of the motorcortical larynx area in the rhesus monkey.” Brain Research, Sep 13;949(1-2):23-31. Full text.pdf